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05 資料３_木所参考人提出資料 (2 ページ)
出典
| 公開元URL | https://www.mhlw.go.jp/stf/newpage_43169.html |
| 出典情報 | 厚生科学審議会 予防接種・ワクチン分科会 研究開発及び生産・流通部会（第35回 9／2）《厚生労働省》 |
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鳥居株に起因する髄膜炎由来株に特徴的な変異
Torii/ori
鳥居株ｺﾝｾﾝｻｽ配列
髄
膜
炎
由
来
株
Ksh_BM
Ksh_BM
Kyt12(AM)
Snd16(AM)
Ibr14(AM)
Snd13(AM)
Snd673(AM)
Kmm87(AM)
SH遺伝子
1 CAAGTAGTGTCG A TGATCTCATTAGGTACTAATCCTAACATTGTGATTCATCCTGCATTGAGAAAAGATTTAGAAAAAAACTAAATTAAGAATGAATCCCCTAGGGTCGTAACGTCTCGTGACCCTGCCGTTGCACTATG CCGGCGATCC 15 0
1 ............ A ............................................................................................................................... .......... 15 0
1 ............ X
C ............................................................................................................................... .......... 15 0
1 ............ X
C ............................................................................................................................... .......... 15 0
1 ............ X
C ............................................................................................................................... .......... 15 0
1 ............ X
C ............................................................................................................................... .......... 15 0
1 ............ X
C ............................................................................................................................... .......... 150
1 ............ X
C ............................................................................................................................... .......... 15 0
************.*************************************************************************************************** ************************************* *
Torii/ori 151 AACCTCCCTTATACCCAACATTTCTATTGCTAATTCTTCTCTCTCTGATCATAACTTTGTATGTCTGGATTATATCAACCATCACTTACAAGACTGCGGTGCGACATGCATCACTGTACCA
鳥居株ｺﾝｾﾝｻｽ配列
髄
膜
炎
由
来
株
GAGATCCTTCTCTCGCTGGAGTTTCGATC 30 0
Ksh_BM
Ksh_BM
151 ...................................................................................................................... ................................ 30 0
Kyt12(AM) 151 ......................................................................................................................... ............................. 30 0
Snd16(AM) 151 ......................................................................................................................... ............................. 30 0
Ibr14(AM) 151 ......................................................................................................................... ............................. 30 0
Snd13(AM) 151 ......................................................................................................................... ............................. 30 0
Snd673(AM) 151 .......................................................................................................................... ............................ 30 0
Kmm87(AM) 151 ......................................................................................................................... ............................. 30 0
**************************************************************************************************************** ************************************* *
ワクチンに含まれる特定の変異体(AMV)が髄膜炎の原因？
Torii/ori 301 ACTCACTCTAGAAAGATCTCCAGTTGGGACAAGTCCCAATCCATCATGCGAGAACAAGCTGCATTTAAATGATGCCGTTCAATCATGAGACATAAAGAAAAAATCAGGCCAGAACAAGCTT
鳥居株ｺﾝｾﾝｻｽ配列
髄
膜
炎
由
来
株
AGGATCACAATACAACACATAACCCCAGC 45 0
Ksh_BM
Ksh_BM
301 ...................................................................................................................... ................................ 45 0
Kyt12(AM) 301 ......................................................................................................................... ............................. 45 0
Snd16(AM) 301 ......................................................................................................................... ............................. 45 0
Ibr14(AM) 301 ......................................................................................................................... ............................. 45 0
Snd13(AM) 301 ......................................................................................................................... ............................. 45 0
Snd673(AM) 301 .......................................................................................................................... ............................ 45 0
Kmm87(AM) 301 ......................................................................................................................... ............................. 45 0
**************************************************************************************************************** ************************************* *
NGSによる髄膜炎由来株と元のワクチンのヴァリアント解析
鳥居株ｺﾝｾﾝｻｽ配列
Torii/ori 451 TGCTATCACAACTGTTCTCTGGCCGCTCGAAAGATGGAGCCCTCAAAACTCTTCACAATGTCAGACAATGCCACCTTTGCACCTGGG C CTGTTGTCAATG
髄
膜
炎
由
来
株
55 0
55 0
55 0
55 0
55 0
55 0
55 0
55 0
Ksh_BM
Ksh_BM
451 ....................................................................................... C ............
Kyt12(AM) 451 ....................................................................................... Z
A ............
Snd16(AM) 451 ....................................................................................... Z
A ............
Ibr14(AM) 451 ...................................................................................... .Z
A ............
Snd13(AM) 451 ....................................................................................... Z
A ............
Snd673(AM) 451 ....................................................................................... Z
A ............
Kmm87(AM) 451 ....................................................................................... Z
A ............
***************************************************************************************.*********** *
2
Torii/ori
鳥居株ｺﾝｾﾝｻｽ配列
髄
膜
炎
由
来
株
Ksh_BM
Ksh_BM
Kyt12(AM)
Snd16(AM)
Ibr14(AM)
Snd13(AM)
Snd673(AM)
Kmm87(AM)
SH遺伝子
1 CAAGTAGTGTCG A TGATCTCATTAGGTACTAATCCTAACATTGTGATTCATCCTGCATTGAGAAAAGATTTAGAAAAAAACTAAATTAAGAATGAATCCCCTAGGGTCGTAACGTCTCGTGACCCTGCCGTTGCACTATG CCGGCGATCC 15 0
1 ............ A ............................................................................................................................... .......... 15 0
1 ............ X
C ............................................................................................................................... .......... 15 0
1 ............ X
C ............................................................................................................................... .......... 15 0
1 ............ X
C ............................................................................................................................... .......... 15 0
1 ............ X
C ............................................................................................................................... .......... 15 0
1 ............ X
C ............................................................................................................................... .......... 150
1 ............ X
C ............................................................................................................................... .......... 15 0
************.*************************************************************************************************** ************************************* *
Torii/ori 151 AACCTCCCTTATACCCAACATTTCTATTGCTAATTCTTCTCTCTCTGATCATAACTTTGTATGTCTGGATTATATCAACCATCACTTACAAGACTGCGGTGCGACATGCATCACTGTACCA
鳥居株ｺﾝｾﾝｻｽ配列
髄
膜
炎
由
来
株
GAGATCCTTCTCTCGCTGGAGTTTCGATC 30 0
Ksh_BM
Ksh_BM
151 ...................................................................................................................... ................................ 30 0
Kyt12(AM) 151 ......................................................................................................................... ............................. 30 0
Snd16(AM) 151 ......................................................................................................................... ............................. 30 0
Ibr14(AM) 151 ......................................................................................................................... ............................. 30 0
Snd13(AM) 151 ......................................................................................................................... ............................. 30 0
Snd673(AM) 151 .......................................................................................................................... ............................ 30 0
Kmm87(AM) 151 ......................................................................................................................... ............................. 30 0
**************************************************************************************************************** ************************************* *
ワクチンに含まれる特定の変異体(AMV)が髄膜炎の原因？
Torii/ori 301 ACTCACTCTAGAAAGATCTCCAGTTGGGACAAGTCCCAATCCATCATGCGAGAACAAGCTGCATTTAAATGATGCCGTTCAATCATGAGACATAAAGAAAAAATCAGGCCAGAACAAGCTT
鳥居株ｺﾝｾﾝｻｽ配列
髄
膜
炎
由
来
株
AGGATCACAATACAACACATAACCCCAGC 45 0
Ksh_BM
Ksh_BM
301 ...................................................................................................................... ................................ 45 0
Kyt12(AM) 301 ......................................................................................................................... ............................. 45 0
Snd16(AM) 301 ......................................................................................................................... ............................. 45 0
Ibr14(AM) 301 ......................................................................................................................... ............................. 45 0
Snd13(AM) 301 ......................................................................................................................... ............................. 45 0
Snd673(AM) 301 .......................................................................................................................... ............................ 45 0
Kmm87(AM) 301 ......................................................................................................................... ............................. 45 0
**************************************************************************************************************** ************************************* *
NGSによる髄膜炎由来株と元のワクチンのヴァリアント解析
鳥居株ｺﾝｾﾝｻｽ配列
Torii/ori 451 TGCTATCACAACTGTTCTCTGGCCGCTCGAAAGATGGAGCCCTCAAAACTCTTCACAATGTCAGACAATGCCACCTTTGCACCTGGG C CTGTTGTCAATG
髄
膜
炎
由
来
株
55 0
55 0
55 0
55 0
55 0
55 0
55 0
55 0
Ksh_BM
Ksh_BM
451 ....................................................................................... C ............
Kyt12(AM) 451 ....................................................................................... Z
A ............
Snd16(AM) 451 ....................................................................................... Z
A ............
Ibr14(AM) 451 ...................................................................................... .Z
A ............
Snd13(AM) 451 ....................................................................................... Z
A ............
Snd673(AM) 451 ....................................................................................... Z
A ............
Kmm87(AM) 451 ....................................................................................... Z
A ............
***************************************************************************************.*********** *
2