（別添）
表 1．各対象医薬品における患者数及び患者背景
HCTZ 含有製剤
N = 2,950,642
年齢, n (%)
20-24 歳
25-29 歳
30-34 歳
35-39 歳
40-44 歳
45-49 歳
50-54 歳
55-59 歳
60-64 歳
65-69 歳
70-74 歳
75-79 歳
80-84 歳
85-89 歳
90-94 歳
95-99 歳
100 歳以上
性別, n (%)
男性
女性
既往歴, n (%)
2 型糖尿病
COPD
慢性腎臓病
アルコール依存症
HIV
がん
医薬品の処方, n (%)
アザチオプリン
シクロスポリン
ミコフェノール酸
モフェチル
タクロリムス
診療行為の実施, n (%)
紫外線療法

ACE 阻害剤
N = 4,664,008

ARB
N = 22,952,153

Ca 拮抗薬
N = 28,091,326

β 遮断薬
N = 8,270,649

509 (0.04%)
1,643 (0.12%)
5,312 (0.39%)
15,347 (1.14%)
35,197 (2.61%)
58,716 (4.35%)
81,771 (6.06%)
104,124 (7.71%)
151,345 (11.21%)
171,219 (12.68%)
184,393 (13.66%)
196,612 (14.56%)
175,767 (13.02%)
112,323 (8.32%)
44,535 (3.30%)
10,079 (0.75%)
1,187 (0.09%)

5,348 (0.11%)
10,005 (0.21%)
21,446 (0.46%)
50,165 (1.08%)
99,194 (2.13%)
161,567 (3.46%)
232,337 (4.98%)
336,045 (7.21%)
526,236 (11.28%)
597,329 (12.81%)
626,420 (13.43%)
662,734 (14.21%)
613,080 (13.14%)
440,611 (9.45%)
212,125 (4.55%)
61,246 (1.31%)
8,120 (0.17%)

20,812 (0.09%)
49,574 (0.22%)
127,649 (0.56%)
337,904 (1.47%)
726,031 (3.16%)
1,189,572 (5.18%)
1,629,540 (7.10%)
2,102,328 (9.16%)
3,024,125 (13.18%)
3,195,179 (13.92%)
3,209,983 (13.99%)
3,037,943 (13.24%)
2,348,653 (10.23%)
1,332,804 (5.81%)
492,988 (2.15%)
114,393 (0.50%)
12,675 (0.06%)

23,820 (0.08%)
67,230 (0.24%)
167,474 (0.60%)
401,059 (1.43%)
823,742 (2.93%)
1,360,618 (4.84%)
1,888,521 (6.72%)
2,496,713 (8.89%)
3,681,344 (13.1%)
3,947,698 (14.05%)
3,966,731 (14.12%)
3,788,100 (13.48%)
2,949,369 (10.5%)
1,691,946 (6.02%)
653,668 (2.33%)
163,553 (0.58%)
19,740 (0.07%)

20,897 (0.25%)
35,578 (0.43%)
65,169 (0.79%)
132,037 (1.60%)
243,749 (2.95%)
365,715 (4.42%)
486,872 (5.89%)
643,597 (7.78%)
972,586 (11.76%)
1,116,218 (13.5%)
1,185,556 (14.33%)
1,196,799 (14.47%)
973,485 (11.77%)
568,492 (6.87%)
211,078 (2.55%)
47,736 (0.58%)
5,085 (0.06%)

1,486,996 (48.45%)
1,581,871 (51.55%)

659,400 (48.84%)
690,679 (51.16%)

2,522,635 (54.09%)
2,141,373 (45.91%)

11,709,043 (51.02%)
11,243,110 (48.98%)

13,726,313 (48.86%)
14,365,013 (51.14%)

4,389,687 (53.08%)
3,880,962 (46.92%)

359,856 (12.2%)
47,460 (1.61%)
109,595 (3.71%)
45,528 (1.54%)
9,915 (0.34%)
879,077 (29.79%)

599,844 (19.55%)
87,993 (2.87%)
281,175 (9.16%)
61,010 (1.99%)
22,591 (0.74%)
1,313,866 (42.81%)

222,020 (16.44%)
32,717 (2.42%)
89,272 (6.61%)
25,895 (1.92%)
7,560 (0.56%)
538,697 (39.9%)

741,618 (15.9%)
112,950 (2.42%)
305,444 (6.55%)
74,200 (1.59%)
27,473 (0.59%)
1,537,469 (32.96%)

2,504,745 (10.91%)
340,588 (1.48%)
787,407 (3.43%)
325,742 (1.42%)
88,132 (0.38%)
6,626,979 (28.87%)

2,482,135 (8.84%)
379,745 (1.35%)
799,392 (2.85%)
363,874 (1.30%)
99,775 (0.36%)
7,392,702 (26.32%)

1,407,865 (17.02%)
202,303 (2.45%)
563,475 (6.81%)
152,389 (1.84%)
55,271 (0.67%)
3,095,348 (37.43%)

963 (0.03%)
3,781 (0.13%)

2,115 (0.07%)
7,921 (0.26%)

613 (0.05%)
2,476 (0.18%)

2,917 (0.06%)
8,862 (0.19%)

10,972 (0.05%)
38,090 (0.17%)

12,679 (0.05%)
44,303 (0.16%)

5,477 (0.07%)
15,764 (0.19%)

377 (0.01%)

1,520 (0.05%)

367 (0.03%)

2,112 (0.05%)

7,769 (0.03%)

7,928 (0.03%)

4,283 (0.05%)

20,841 (0.71%)

33,312 (1.09%)

14,521 (1.08%)

37,213 (0.80%)

195,539 (0.85%)

231,723 (0.82%)

87,629 (1.06%)

47,466 (1.61%)

71,105 (2.32%)

32,200 (2.39%)

78,549 (1.68%)

384,058 (1.67%)

437,531 (1.56%)

173,569 (2.10%)

チアジド系利尿薬
N = 3,068,867

チアジド系類似薬
N = 1,350,079

847 (0.03%)
3,434 (0.12%)
11,386 (0.39%)
36,083 (1.22%)
82,677 (2.80%)
139,888 (4.74%)
197,103 (6.68%)
253,133 (8.58%)
369,271 (12.51%)
382,745 (12.97%)
407,431 (13.81%)
420,793 (14.26%)
350,523 (11.88%)
205,592 (6.97%)
73,143 (2.48%)
15,156 (0.51%)
1,437 (0.05%)

1,286 (0.04%)
3,823 (0.12%)
11,142 (0.36%)
30,754 (1.00%)
69,533 (2.27%)
115,295 (3.76%)
159,797 (5.21%)
205,075 (6.68%)
305,818 (9.97%)
359,002 (11.7%)
406,961 (13.26%)
463,060 (15.09%)
443,239 (14.44%)
314,431 (10.25%)
139,450 (4.54%)
35,856 (1.17%)
4,345 (0.14%)

1,504,575 (50.99%)
1,446,067 (49.01%)

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