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【参考１】新型コロナウイルス感染症COVID-19診療の手引き 第10.0版 (18 ページ)
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●新型コロナウイルス感染症（COVID-19） 診療の手引き・第 10.0 版 ●２ 臨床像
2. 重症化のリスク因子
・ COVIREGI-JP/REBIND 登録患者におけるオミクロン株症例重症化リスク因子の検討（第 83 回新型コロナウイルス感染症
対策アドバイザリーボード資料）
・Malik P, et al. Biomarkers and outcomes of COVID-19 hospitalisations: systematic review and meta-analysis. BMJ
Evid Based Med 2021.
・Peckham H, et al. Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU
admission. Nat Commun 2020.
・Sugiyama M, et al. Serum CCL17 level becomes a predictive marker to distinguish between mild/moderate and
severe/critical disease in patients with COVID-19. Gene 2021．
・Terada M, et al. Risk factors for severity on admission and the disease progression during hospitalisation in a large
cohort of patients with COVID-19 in Japan. BMJ Open 2021.
・US CDC. Science Brief: Evidence used to update the list of underlying medical conditions associated with higher
risk for severe COVID-19. 9 Feb 2023.
3. 小児例の特徴
・国立感染症研究所．小児の重症度，小児における死亡例・新型コロナウイルス感染後の 20 歳未満の死亡例に関する積極的
疫学調査（第二報）．2022.12.28.
・日本小児科学会予防接種・感染症対策委員会．新型コロナワクチン接種に関する，小児の基礎疾患の考え方および接種に
あたり考慮すべき小児の基礎疾患等．2022.8.17 改訂．
・日本小児科学会予防接種・感染症対策委員会．小児への新型コロナワクチン接種に対する考え方（2023.6.9. 追補）．
2023.6.9.
・Bellino S, et al. COVID-19 disease severity risk factors for pediatric patients in Italy. Pediatrics 2020.
・Katsuta T, et al. Acute and postacute clinical characteristics of Coronavirus disease 2019 in children in Japan.
Pediatr Infect Dis J 2022.
・United Nations Children’s Fund, The State of the World’s Children 2023: For every child, vaccination, UNICEF
Innocenti – Global office of research and foresight, Florence, April 2023.
4. 妊婦例の特徴
・日本産科婦人科学会周産期委員会・周産期における感染に関する小委員会．妊婦の新型コロナウイルスワクチン接種に関す
る WEB アンケート調査結果について．2022.1.12.
・出口雅士，山田秀人．日本における COVID-19 妊婦の現状 ～妊婦レジストリの解析結果（2022 年 5 月 5 日迄の登録症例）．
2022.6.7.
・Allotey J, et al. Clinical manifestations，risk factors，and maternal and perinatal outcomes of coronavirus disease
2019 in pregnancy: living systematic review and meta-analysis. BMJ 2020.
・Engjom H, et al. Severe COVID-19 in pregnancy is almost exclusively limited to unvaccinated women-time for
policies to change. Lancet Reg Health Eur 2022．
・Goldshtein I, et al. Association of BNT162b2 COVID-19 vaccination during pregnancy with neonatal and early
infant outcomes. JAMA Pediatr 2022.
・Halasa NB, et al. Maternal vaccination and risk of hospitalization for Covid-19 among infants. N Engl J Med 2022.
・Hayakawa S, et al. Covid-19 pandemic and pregnancy. J Obstet Gynaecol Res 2020.
・Hayakawa S, et al. Anti-SARS-CoV-2 vaccination strategy for pregnant women in Japan. J Obstet Gynaecol Res
2021.
・Komine-Aizawa S, et al. Placental barrier against COVID-19. Placenta 2020.
・Wei SQ, et al. The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis. CMAJ
2021.
・Zambrano LD, et al. Update: Characteristics of symptomatic women of reproductive age with laboratoryconfirmed SARS-CoV-2 infection by pregnancy status — United States，January 22–October 3, 2020. MMWR
2020．
・Shoji K, et al. Clinical characteristics and outcomes of COVID-19 in pregnant women: a propensity score matched
analysis of the data from the COVID-19 Registry Japan. Clin Infect Dis 2022.
・Villar J, et al. Pregnancy outcomes and vaccine effectiveness during the period of omicron as the variant of concern,
INTERCOVID-2022: a multinational, observational study. Lancet 2023.
5. 罹患後症状
・新型コロナウイルス感染症診療の手引き 別冊：罹患後症状のマネジメント 第 2 版．2022.10.14.
・Morioka S, et al. Post COVID-19 condition of the Omicron variant of SARS-CoV-2. J Infect Chemother 2022.
・Nalbandian A, et al. Post-acute COVID-19 syndrome. Nat Med 2021.
・Soriano JB, et al. A clinical case definition of post-COVID-19 condition by a Delphi consensus. Lancet Infect Dis
2022.
◀︎ CONTENTS
18
2. 重症化のリスク因子
・ COVIREGI-JP/REBIND 登録患者におけるオミクロン株症例重症化リスク因子の検討（第 83 回新型コロナウイルス感染症
対策アドバイザリーボード資料）
・Malik P, et al. Biomarkers and outcomes of COVID-19 hospitalisations: systematic review and meta-analysis. BMJ
Evid Based Med 2021.
・Peckham H, et al. Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU
admission. Nat Commun 2020.
・Sugiyama M, et al. Serum CCL17 level becomes a predictive marker to distinguish between mild/moderate and
severe/critical disease in patients with COVID-19. Gene 2021．
・Terada M, et al. Risk factors for severity on admission and the disease progression during hospitalisation in a large
cohort of patients with COVID-19 in Japan. BMJ Open 2021.
・US CDC. Science Brief: Evidence used to update the list of underlying medical conditions associated with higher
risk for severe COVID-19. 9 Feb 2023.
3. 小児例の特徴
・国立感染症研究所．小児の重症度，小児における死亡例・新型コロナウイルス感染後の 20 歳未満の死亡例に関する積極的
疫学調査（第二報）．2022.12.28.
・日本小児科学会予防接種・感染症対策委員会．新型コロナワクチン接種に関する，小児の基礎疾患の考え方および接種に
あたり考慮すべき小児の基礎疾患等．2022.8.17 改訂．
・日本小児科学会予防接種・感染症対策委員会．小児への新型コロナワクチン接種に対する考え方（2023.6.9. 追補）．
2023.6.9.
・Bellino S, et al. COVID-19 disease severity risk factors for pediatric patients in Italy. Pediatrics 2020.
・Katsuta T, et al. Acute and postacute clinical characteristics of Coronavirus disease 2019 in children in Japan.
Pediatr Infect Dis J 2022.
・United Nations Children’s Fund, The State of the World’s Children 2023: For every child, vaccination, UNICEF
Innocenti – Global office of research and foresight, Florence, April 2023.
4. 妊婦例の特徴
・日本産科婦人科学会周産期委員会・周産期における感染に関する小委員会．妊婦の新型コロナウイルスワクチン接種に関す
る WEB アンケート調査結果について．2022.1.12.
・出口雅士，山田秀人．日本における COVID-19 妊婦の現状 ～妊婦レジストリの解析結果（2022 年 5 月 5 日迄の登録症例）．
2022.6.7.
・Allotey J, et al. Clinical manifestations，risk factors，and maternal and perinatal outcomes of coronavirus disease
2019 in pregnancy: living systematic review and meta-analysis. BMJ 2020.
・Engjom H, et al. Severe COVID-19 in pregnancy is almost exclusively limited to unvaccinated women-time for
policies to change. Lancet Reg Health Eur 2022．
・Goldshtein I, et al. Association of BNT162b2 COVID-19 vaccination during pregnancy with neonatal and early
infant outcomes. JAMA Pediatr 2022.
・Halasa NB, et al. Maternal vaccination and risk of hospitalization for Covid-19 among infants. N Engl J Med 2022.
・Hayakawa S, et al. Covid-19 pandemic and pregnancy. J Obstet Gynaecol Res 2020.
・Hayakawa S, et al. Anti-SARS-CoV-2 vaccination strategy for pregnant women in Japan. J Obstet Gynaecol Res
2021.
・Komine-Aizawa S, et al. Placental barrier against COVID-19. Placenta 2020.
・Wei SQ, et al. The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis. CMAJ
2021.
・Zambrano LD, et al. Update: Characteristics of symptomatic women of reproductive age with laboratoryconfirmed SARS-CoV-2 infection by pregnancy status — United States，January 22–October 3, 2020. MMWR
2020．
・Shoji K, et al. Clinical characteristics and outcomes of COVID-19 in pregnant women: a propensity score matched
analysis of the data from the COVID-19 Registry Japan. Clin Infect Dis 2022.
・Villar J, et al. Pregnancy outcomes and vaccine effectiveness during the period of omicron as the variant of concern,
INTERCOVID-2022: a multinational, observational study. Lancet 2023.
5. 罹患後症状
・新型コロナウイルス感染症診療の手引き 別冊：罹患後症状のマネジメント 第 2 版．2022.10.14.
・Morioka S, et al. Post COVID-19 condition of the Omicron variant of SARS-CoV-2. J Infect Chemother 2022.
・Nalbandian A, et al. Post-acute COVID-19 syndrome. Nat Med 2021.
・Soriano JB, et al. A clinical case definition of post-COVID-19 condition by a Delphi consensus. Lancet Infect Dis
2022.
◀︎ CONTENTS
18