よむ、つかう、まなぶ。
資料4-5 メトホルミン塩酸塩 (32 ページ)
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first-line ovulation induction, achievement of pregnancy, and live birth in Asian women with
polycystic ovary syndrome: a randomized controlled trial. Fertil Steril. 2009; 91: 514-21.
27） Sahin Y, et al. The effects of metformin on insulin resistance, clomiphene-induced ovulation
and pregnancy rates in women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod
Biol. 2004; 113: 214-20.
28） Dasari P, et al. The efficacy of metformin and clomiphene citrate combination compared with
clomiphene citrate alone for ovulation induction in infertile patients with PCOS. J Hum Reprod
Sci. 2009; 2: 18-22.
29） Vandermolen DT, et al. Metformin increases the ovulatory rate and pregnancy rate from
clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene
citrate alone. Fertil Steril. 2001; 75: 310-5.
30） George SS, et al. Sequential treatment of metformin and clomiphene citrate in clomipheneresistant women with polycystic ovary syndrome: a randomized, controlled trial. Hum Reprod
2003; 18: 299-304.
31） Sohrabvand F, et al. Efficacy of combined metformin–letrozole in comparison with metformin–
clomiphene citrate in clomiphene-resistant infertile women with polycystic ovarian disease. Hum
Reprod 2006; 21: 1432-5.
32） Malkawi HY, et al. The effect of metformin plus clomiphene citrate on ovulation and pregnancy
rates in clomiphene-resistant women with polycystic ovary syndrome. Saudi Med J. 2002; 23:
663-6.
33） Cheng J, et al. Clinical outcomes of ovulation induction with metformin, clomiphene citrate and
human menopausal gonadotrophin in polycystic ovary syndrome. J Int Med Resear 2010; 38:
1250-8.
34） zum Einsatz von Metformin vor und während der Schwangerschaft bei Frauen mit PCOS und
Kinderwunsch 2015
35） Lord JM, et al. Metformin in polycystic ovary syndrome: systematic review and meta-analysis.
BMJ 2003; 327: 951-3.
36） Harborne L, et al. Descriptive review of the evidence for the use of metformin in polycystic
ovary syndrome. Lancet 2003; 361: 1894-901.
37） Palomba S, et al. Clomiphene citrate, metformin or both as first-step approach in treating
anovulatory infertility in patients with polycystic ovary syndrome (PCOS): a systematic review
of head-to-head randomized controlled studies and meta-analysis. Clin Endocrinol. 2009;70:
311-21
38） Recommandations pour la pratique Clinique La prise en charge du couple infertile 2010.
39） No. 362-Ovulation Induction in Polycystic Ovary Syndrome. J Obstet Gynaecol Can 2018; 40:
978-87.
40） Wang R, et al. Treatment strategies for women with WHO group II anovulation: systematic
32
polycystic ovary syndrome: a randomized controlled trial. Fertil Steril. 2009; 91: 514-21.
27） Sahin Y, et al. The effects of metformin on insulin resistance, clomiphene-induced ovulation
and pregnancy rates in women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod
Biol. 2004; 113: 214-20.
28） Dasari P, et al. The efficacy of metformin and clomiphene citrate combination compared with
clomiphene citrate alone for ovulation induction in infertile patients with PCOS. J Hum Reprod
Sci. 2009; 2: 18-22.
29） Vandermolen DT, et al. Metformin increases the ovulatory rate and pregnancy rate from
clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene
citrate alone. Fertil Steril. 2001; 75: 310-5.
30） George SS, et al. Sequential treatment of metformin and clomiphene citrate in clomipheneresistant women with polycystic ovary syndrome: a randomized, controlled trial. Hum Reprod
2003; 18: 299-304.
31） Sohrabvand F, et al. Efficacy of combined metformin–letrozole in comparison with metformin–
clomiphene citrate in clomiphene-resistant infertile women with polycystic ovarian disease. Hum
Reprod 2006; 21: 1432-5.
32） Malkawi HY, et al. The effect of metformin plus clomiphene citrate on ovulation and pregnancy
rates in clomiphene-resistant women with polycystic ovary syndrome. Saudi Med J. 2002; 23:
663-6.
33） Cheng J, et al. Clinical outcomes of ovulation induction with metformin, clomiphene citrate and
human menopausal gonadotrophin in polycystic ovary syndrome. J Int Med Resear 2010; 38:
1250-8.
34） zum Einsatz von Metformin vor und während der Schwangerschaft bei Frauen mit PCOS und
Kinderwunsch 2015
35） Lord JM, et al. Metformin in polycystic ovary syndrome: systematic review and meta-analysis.
BMJ 2003; 327: 951-3.
36） Harborne L, et al. Descriptive review of the evidence for the use of metformin in polycystic
ovary syndrome. Lancet 2003; 361: 1894-901.
37） Palomba S, et al. Clomiphene citrate, metformin or both as first-step approach in treating
anovulatory infertility in patients with polycystic ovary syndrome (PCOS): a systematic review
of head-to-head randomized controlled studies and meta-analysis. Clin Endocrinol. 2009;70:
311-21
38） Recommandations pour la pratique Clinique La prise en charge du couple infertile 2010.
39） No. 362-Ovulation Induction in Polycystic Ovary Syndrome. J Obstet Gynaecol Can 2018; 40:
978-87.
40） Wang R, et al. Treatment strategies for women with WHO group II anovulation: systematic
32