よむ、つかう、まなぶ。
【参考資料３】【英版R4.1.17】Nippon AMR One Health Report (NAOR) 2020 (29 ページ)
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ⅳ. Salmonella Typhi, Salmonella Paratyphi A, Shigella spp.
Source: National Institute of Infectious Diseases
The 28-46 Salmonella Typhi strains that were isolated between 2015 and 2019 were tested for antimicrobial
susceptibility (Table 24). CPFX-non-susceptible strains accounted for 60.7-83.9%, while strains with advanced
resistance (MIC ≥ 4) to ciprofloxacin accounted for 5.9-23.9%. During this period, 11 strains of multidrug-resistant
Salmonella Typhi that indicated resistance to ampicillin (ABPC), CP and ST were isolated, along with two strains
of CTX-resistant Salmonella Typhi.
The 13-30 Salmonella Paratyphi A strains isolated between 2015 and 2019 were tested for antimicrobial
susceptibility. CPFX-non-susceptible strains accounted for 76.9-100% and one strain with advanced CPFX
resistance (MIC ≥ 4) was isolated. No cefotaxime-resistant strains were isolated among the Salmonella Paratyphi
A.
The 73-156 Shigella spp. strains that were isolated between 2015 and 2019 were tested for antimicrobial
susceptibility. ST-resistant strains accounted for 73.6-81.0%; CPFX-non-susceptible strains for 14.3-45.7%; and
cefotaxime-resistant strains for 3.3-16.4%.
Table 31. The proportion (%) of antimicrobial-resistant Salmonella Typhi
2015
(32 strains)
ABPC
5.7
CP
5.7
ST
5.7
NA
68.8
CPFX
68.8 (12.5*)
CTX
0.0
* Advanced resistance to fluoroquinolone
2016
(46 strains)
2.2
2.2
2.2
63.0
63.0 (23.9*)
0.0
2017
(31 strains)
12.9
12.9
12.9
83.9
83.9 (16.1*)
0.0
2018
(34 strains)
2.9
5.9
5.9
61.7
61.7 (5.9*)
2.9
2019
(28 strains)
10.7
10.7
10.7
57.1
60.7 (10.7*)
3.6
Table 32. The proportion (%) of antimicrobial-resistant Salmonella Paratyphi A
ABPC
CP
ST
NA
CPFX
CTX
2015
(30 strains)
0.0
0.0
0.0
80.0
83.3
0.0
2016
(20 strains)
0.0
0.0
0.0
80.0
83.3
0.0
2017
(13 strains)
0.0
0.0
0.0
76.9
76.9
0.0
2018
(21 strains)
0.0
0.0
0.0
100
100
0.0
2019
(16 strains)
0.0
0.0
0.0
87.5
87.5
0.0
2018
(156 strains)
19.2
2019
(91 strains)
14.3
Table 33. The proportion (%) of antimicrobial-resistant Shigella spp.
ABPC
2015
(105 strains)
21.9
2016
(73 strains)
42.5
2017
(91 strains)
31.9
CP
11.4
24.7
26.4
9.0
6.6
ST
81.0
80.8
73.6
76.9
76.9
NA
63.8
52.1
52.8
45.5
33.0
CPFX
45.7
35.6
35.2
21.2
14.3
CTX
5.7
16.4
13.2
5.1
3.3
28
Source: National Institute of Infectious Diseases
The 28-46 Salmonella Typhi strains that were isolated between 2015 and 2019 were tested for antimicrobial
susceptibility (Table 24). CPFX-non-susceptible strains accounted for 60.7-83.9%, while strains with advanced
resistance (MIC ≥ 4) to ciprofloxacin accounted for 5.9-23.9%. During this period, 11 strains of multidrug-resistant
Salmonella Typhi that indicated resistance to ampicillin (ABPC), CP and ST were isolated, along with two strains
of CTX-resistant Salmonella Typhi.
The 13-30 Salmonella Paratyphi A strains isolated between 2015 and 2019 were tested for antimicrobial
susceptibility. CPFX-non-susceptible strains accounted for 76.9-100% and one strain with advanced CPFX
resistance (MIC ≥ 4) was isolated. No cefotaxime-resistant strains were isolated among the Salmonella Paratyphi
A.
The 73-156 Shigella spp. strains that were isolated between 2015 and 2019 were tested for antimicrobial
susceptibility. ST-resistant strains accounted for 73.6-81.0%; CPFX-non-susceptible strains for 14.3-45.7%; and
cefotaxime-resistant strains for 3.3-16.4%.
Table 31. The proportion (%) of antimicrobial-resistant Salmonella Typhi
2015
(32 strains)
ABPC
5.7
CP
5.7
ST
5.7
NA
68.8
CPFX
68.8 (12.5*)
CTX
0.0
* Advanced resistance to fluoroquinolone
2016
(46 strains)
2.2
2.2
2.2
63.0
63.0 (23.9*)
0.0
2017
(31 strains)
12.9
12.9
12.9
83.9
83.9 (16.1*)
0.0
2018
(34 strains)
2.9
5.9
5.9
61.7
61.7 (5.9*)
2.9
2019
(28 strains)
10.7
10.7
10.7
57.1
60.7 (10.7*)
3.6
Table 32. The proportion (%) of antimicrobial-resistant Salmonella Paratyphi A
ABPC
CP
ST
NA
CPFX
CTX
2015
(30 strains)
0.0
0.0
0.0
80.0
83.3
0.0
2016
(20 strains)
0.0
0.0
0.0
80.0
83.3
0.0
2017
(13 strains)
0.0
0.0
0.0
76.9
76.9
0.0
2018
(21 strains)
0.0
0.0
0.0
100
100
0.0
2019
(16 strains)
0.0
0.0
0.0
87.5
87.5
0.0
2018
(156 strains)
19.2
2019
(91 strains)
14.3
Table 33. The proportion (%) of antimicrobial-resistant Shigella spp.
ABPC
2015
(105 strains)
21.9
2016
(73 strains)
42.5
2017
(91 strains)
31.9
CP
11.4
24.7
26.4
9.0
6.6
ST
81.0
80.8
73.6
76.9
76.9
NA
63.8
52.1
52.8
45.5
33.0
CPFX
45.7
35.6
35.2
21.2
14.3
CTX
5.7
16.4
13.2
5.1
3.3
28