よむ、つかう、まなぶ。
【参考資料３】【英版R4.1.17】Nippon AMR One Health Report (NAOR) 2020 (52 ページ)
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Table 63. Resistance rates of Klebsiella spp. derived from diseased dogs and cats (%)
Agent
BP
＊
CEZ
32
CEX
32†
CTX
4＊
MEPM
4＊
SM
32†
GM
16＊
KM
64＊
TC
16＊
CP
32＊
CL
4＊
NA
32＊
CPFX
4＊
ST
76/4＊
Strains tested (n)
Animal
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
2017
47.2
84.6
44.4
84.6
41.7
80.8
0.0
0.0
26.4
57.7
26.4
61.5
8.3
23.1
33.3
57.7
25.0
26.9
1.4
3.8
51.4
84.6
44.4
84.6
41.7
76.9
72
26
2018
51.0
90.0
46.9
80.0
38.8
80.0
0.0
0.0
34.7
55.0
28.6
55.0
12.2
20.0
42.9
65.0
32.7
45.0
0.0
0.0
61.2
95.0
57.1
90.0
46.9
70.0
49
20
2019
42.0
67.6
42.0
56.8
34.6
56.8
0.0
0.0
29.6
59.5
21.0
40.5
6.2
13.5
30.9
48.6
19.8
16.2
0.0
0.0
46.9
81.1
46.9
75.7
37.0
56.8
81
37
The unit of BP is μg/mL.
* BP follows CLSI Criteria.
†
EUCAST values were used as the BP for CEX. As EUCAST has not set a BP for SM, the JVARM value (midpoint of a bimodal MIC
distribution obtained in FY2001) was used. Surveillance also covered ABPC, but the figures are not given here, due to the intrinsic
resistance of K. pneumoniae and K. oxytoca.
ⅲ. Coagulase-positive Staphylococcus spp.
The most common coagulase-positive Staphylococcus spp. in both dogs and cats was S. pseudintermedius. S.
aureus, S. schleiferi subsp. coagulans, and S. intermedius were also collected.
In the case of S. pseudintermedius, resistance to oxacillin (MPIPC), GM, TC, CP, EM, AZM, and CPFX in dogand cat-derived strains was observed to exceed 40% in 2019. More than 70% of strains isolated from both dogs
and cats were observed to be resistant to AZM and CPFX, which are critically important antimicrobials for human
medicine.
In S. aureus isolated from cats, resistance to MPIPC, CEZ, CEX, cefoxitin (CFX), CTX, EM, AZM, and CPFX
was observed to exceed 60% in 2019. On the other hand, no resistance to SM and CP was observed. Rates of
resistance to CTX, AZM, and CPFX, which are critically important antimicrobials for human medicine, were
observed to be more than 70%.
51
Agent
BP
＊
CEZ
32
CEX
32†
CTX
4＊
MEPM
4＊
SM
32†
GM
16＊
KM
64＊
TC
16＊
CP
32＊
CL
4＊
NA
32＊
CPFX
4＊
ST
76/4＊
Strains tested (n)
Animal
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
2017
47.2
84.6
44.4
84.6
41.7
80.8
0.0
0.0
26.4
57.7
26.4
61.5
8.3
23.1
33.3
57.7
25.0
26.9
1.4
3.8
51.4
84.6
44.4
84.6
41.7
76.9
72
26
2018
51.0
90.0
46.9
80.0
38.8
80.0
0.0
0.0
34.7
55.0
28.6
55.0
12.2
20.0
42.9
65.0
32.7
45.0
0.0
0.0
61.2
95.0
57.1
90.0
46.9
70.0
49
20
2019
42.0
67.6
42.0
56.8
34.6
56.8
0.0
0.0
29.6
59.5
21.0
40.5
6.2
13.5
30.9
48.6
19.8
16.2
0.0
0.0
46.9
81.1
46.9
75.7
37.0
56.8
81
37
The unit of BP is μg/mL.
* BP follows CLSI Criteria.
†
EUCAST values were used as the BP for CEX. As EUCAST has not set a BP for SM, the JVARM value (midpoint of a bimodal MIC
distribution obtained in FY2001) was used. Surveillance also covered ABPC, but the figures are not given here, due to the intrinsic
resistance of K. pneumoniae and K. oxytoca.
ⅲ. Coagulase-positive Staphylococcus spp.
The most common coagulase-positive Staphylococcus spp. in both dogs and cats was S. pseudintermedius. S.
aureus, S. schleiferi subsp. coagulans, and S. intermedius were also collected.
In the case of S. pseudintermedius, resistance to oxacillin (MPIPC), GM, TC, CP, EM, AZM, and CPFX in dogand cat-derived strains was observed to exceed 40% in 2019. More than 70% of strains isolated from both dogs
and cats were observed to be resistant to AZM and CPFX, which are critically important antimicrobials for human
medicine.
In S. aureus isolated from cats, resistance to MPIPC, CEZ, CEX, cefoxitin (CFX), CTX, EM, AZM, and CPFX
was observed to exceed 60% in 2019. On the other hand, no resistance to SM and CP was observed. Rates of
resistance to CTX, AZM, and CPFX, which are critically important antimicrobials for human medicine, were
observed to be more than 70%.
51