よむ、つかう、まなぶ。
【参考資料３】【英版R4.1.17】Nippon AMR One Health Report (NAOR) 2020 (53 ページ)
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Table 64. Resistance rates of Staphylococcus pseudintermedius derived from diseased dogs and cats (%)
Agent*
BP
†
MPIPC
0.5
GM
16†
TC
16†
CP
32†
EM
8†
AZM
8†
CPFX
4†
Strains tested (n)
Animal
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
2017
58.2
68.6
26.2
13.7
62.3
52.9
43.4
64.7
67.2
70.6
67.2
66.7
64.8
88.2
122
51
2018
56.6
81.8
54.2
63.6
67.5
81.8
49.4
72.7
74.7
86.4
74.7
86.4
75.9
100.0
83
22
2019
62.8
81.0
64.1
52.4
66.7
85.7
60.3
83.3
79.5
95.2
79.5
95.2
75.6
97.6
78
42
The unit of BP is μg/mL.
†
BP follows CLSI Criteria.
While ABPC, CEZ, CEX, CFX, CMZ, CTX and SM were also included in the scope of monitoring, the proportion of ABPC-, CEZ-, CEX-,
CFX-, CMZ-, CTX- and SM-resistant strains were not listed because BP could not be established.
Table 65. Resistance rates of Staphylococcus aureus derived from diseased cats (%)
Agent
MPIPC
BP
Animal
2017
2018
2019
4†
Cats
61.9
70.6
70.0
$
CEZ
4
Cats
61.9
64.7
66.7
CEX
CFX
16$
8$
Cats
Cats
61.9
61.9
70.6
64.7
70.0
70.0
CTX
8$
Cats
61.9
64.7
70.0
SM
32
$
Cats
4.8
5.9
0.0
GM
TC
16†
16†
Cats
Cats
47.6
14.3
58.8
41.2
36.7
43.3
CP
32†
Cats
0.0
0.0
70.0
EM
8†
Cats
66.7
76.5
70.0
AZM
8†
Cats
66.7
76.5
70.0
†
Cats
61.9
76.5
83.3
Cats
21
17
30
CPFX
4
Strains tested (n)
The unit of BP is μg/mL.
†
BP follows CLSI Criteria. $ Uses EUCAST’s ECOFF value
* While ABPC and CMZ were also included in the scope of monitoring, the proportion of ABPC- and CMZ-resistant strains were not listed
because BP could not be established.
ⅳ. Enterococcus spp.
The most common Enterococcus spp. in both dogs and cats was E. faecalis, followed by E. faecium. In 2018,
rates of resistance to TC were in excess of 60% in both dog- and cat-derived strains, while CP resistance rates was
below 20%. Between 31.1% and 43.7% of dog- and cat-derived strains were observed to be resistant to CPFX, a
critically important antimicrobial for human medicine. Measurement of VCM as a test drug began in 2019, but no
resistant bacteria were found in strains from dogs and cats.
52
Agent*
BP
†
MPIPC
0.5
GM
16†
TC
16†
CP
32†
EM
8†
AZM
8†
CPFX
4†
Strains tested (n)
Animal
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
2017
58.2
68.6
26.2
13.7
62.3
52.9
43.4
64.7
67.2
70.6
67.2
66.7
64.8
88.2
122
51
2018
56.6
81.8
54.2
63.6
67.5
81.8
49.4
72.7
74.7
86.4
74.7
86.4
75.9
100.0
83
22
2019
62.8
81.0
64.1
52.4
66.7
85.7
60.3
83.3
79.5
95.2
79.5
95.2
75.6
97.6
78
42
The unit of BP is μg/mL.
†
BP follows CLSI Criteria.
While ABPC, CEZ, CEX, CFX, CMZ, CTX and SM were also included in the scope of monitoring, the proportion of ABPC-, CEZ-, CEX-,
CFX-, CMZ-, CTX- and SM-resistant strains were not listed because BP could not be established.
Table 65. Resistance rates of Staphylococcus aureus derived from diseased cats (%)
Agent
MPIPC
BP
Animal
2017
2018
2019
4†
Cats
61.9
70.6
70.0
$
CEZ
4
Cats
61.9
64.7
66.7
CEX
CFX
16$
8$
Cats
Cats
61.9
61.9
70.6
64.7
70.0
70.0
CTX
8$
Cats
61.9
64.7
70.0
SM
32
$
Cats
4.8
5.9
0.0
GM
TC
16†
16†
Cats
Cats
47.6
14.3
58.8
41.2
36.7
43.3
CP
32†
Cats
0.0
0.0
70.0
EM
8†
Cats
66.7
76.5
70.0
AZM
8†
Cats
66.7
76.5
70.0
†
Cats
61.9
76.5
83.3
Cats
21
17
30
CPFX
4
Strains tested (n)
The unit of BP is μg/mL.
†
BP follows CLSI Criteria. $ Uses EUCAST’s ECOFF value
* While ABPC and CMZ were also included in the scope of monitoring, the proportion of ABPC- and CMZ-resistant strains were not listed
because BP could not be established.
ⅳ. Enterococcus spp.
The most common Enterococcus spp. in both dogs and cats was E. faecalis, followed by E. faecium. In 2018,
rates of resistance to TC were in excess of 60% in both dog- and cat-derived strains, while CP resistance rates was
below 20%. Between 31.1% and 43.7% of dog- and cat-derived strains were observed to be resistant to CPFX, a
critically important antimicrobial for human medicine. Measurement of VCM as a test drug began in 2019, but no
resistant bacteria were found in strains from dogs and cats.
52