よむ、つかう、まなぶ。
【参考資料３】【英版R4.1.17】Nippon AMR One Health Report (NAOR) 2020 (54 ページ)
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Table 66. Resistance rates of Enterococcus spp. derived from diseased dogs and cats (%)
Agent*
BP
†
ABPC
16
GM
32§
TC
16†
CP
32†
EM
8†
CPFX
4†
VCM
32†
Strains tested (n)
Animal
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
2017
26.7
17.3
22.9
19.4
65.6
70.4
20.6
20.4
61.8
41.8
42.7
34.7
2018
20.5
31.6
15.4
24.6
67.9
73.7
14.1
15.8
39.7
54.4
28.2
49.1
131
98
78
57
2019
20.0
33.0
25.2
25.2
68.9
64.1
18.5
8.7
43.0
39.8
31.1
43.7
0.0
0.0
135
103
The unit of BP is μg/mL.
AZM was also included in the scope of monitoring, the proportion of AZM-resistant strains were not listed because BP could not be
established.
†
BP follows CLSI Criteria.
§
As EUCAST has not set a BP for GM, the JVARM value (midpoint of a bimodal MIC distribution obtained in FY2002) was used.
* While
b. Bacterial strains from healthy dogs and cats (2018-2019)
Bacterial strains from healthy dogs and cats were collected from veterinary clinics across the country with the
cooperation of the Japan Veterinary Medical Association, with the number of strains allocated on the basis of the
number of notifications of veterinary clinic (small animal and other animals) establishment received by each
prefecture. Rectal swabs were taken from healthy dogs and cats brought to veterinary clinics for health checkups
and vaccination. Escherichia coli and Enterococcus spp. were then isolated from the samples, identified, and sent
for antimicrobial susceptibility tests.
ⅰ. Escherichia coli
Monitoring of 14 agents was carried out. In strains isolated from healthy dogs and cats, the rates of resistance
to ABPC and NA were high in both 2018 and 2019, while rates of resistance to the other antimicrobials were less
than 20%. The rates of resistance to critically important antimicrobials for human medicine in dog- and cat-derived
strains were as follows: 6.4-13.2% to CTX, and 8.8-18.5% to CPFX, while no MEPM- or CL-resistant strains were
isolated. In all drugs which resistant strains had been found, resistance rates of Escherichia coli derived from
healthy dogs and cats were lower than that from diseased dogs and cats collected in same year.
53
Agent*
BP
†
ABPC
16
GM
32§
TC
16†
CP
32†
EM
8†
CPFX
4†
VCM
32†
Strains tested (n)
Animal
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
Dogs
Cats
2017
26.7
17.3
22.9
19.4
65.6
70.4
20.6
20.4
61.8
41.8
42.7
34.7
2018
20.5
31.6
15.4
24.6
67.9
73.7
14.1
15.8
39.7
54.4
28.2
49.1
131
98
78
57
2019
20.0
33.0
25.2
25.2
68.9
64.1
18.5
8.7
43.0
39.8
31.1
43.7
0.0
0.0
135
103
The unit of BP is μg/mL.
AZM was also included in the scope of monitoring, the proportion of AZM-resistant strains were not listed because BP could not be
established.
†
BP follows CLSI Criteria.
§
As EUCAST has not set a BP for GM, the JVARM value (midpoint of a bimodal MIC distribution obtained in FY2002) was used.
* While
b. Bacterial strains from healthy dogs and cats (2018-2019)
Bacterial strains from healthy dogs and cats were collected from veterinary clinics across the country with the
cooperation of the Japan Veterinary Medical Association, with the number of strains allocated on the basis of the
number of notifications of veterinary clinic (small animal and other animals) establishment received by each
prefecture. Rectal swabs were taken from healthy dogs and cats brought to veterinary clinics for health checkups
and vaccination. Escherichia coli and Enterococcus spp. were then isolated from the samples, identified, and sent
for antimicrobial susceptibility tests.
ⅰ. Escherichia coli
Monitoring of 14 agents was carried out. In strains isolated from healthy dogs and cats, the rates of resistance
to ABPC and NA were high in both 2018 and 2019, while rates of resistance to the other antimicrobials were less
than 20%. The rates of resistance to critically important antimicrobials for human medicine in dog- and cat-derived
strains were as follows: 6.4-13.2% to CTX, and 8.8-18.5% to CPFX, while no MEPM- or CL-resistant strains were
isolated. In all drugs which resistant strains had been found, resistance rates of Escherichia coli derived from
healthy dogs and cats were lower than that from diseased dogs and cats collected in same year.
53