よむ、つかう、まなぶ。
【参考１】診療の手引き・第8.1版 (62 ページ)
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●新型コロナウイルス感染症（COVID-19） 診療の手引き・第 8.1 版 ●５ 薬物療法
◆引用・参考文献◆
・日本感染症学会．COVID-19 に対する薬物治療の考え方（第 14.2 版）
．2022.9.30.
・日本救急医学会・日本集中治療医学会．日本版敗血症診療ガイドライン 2020（J-SSCG2020）特別編，COVID-19 薬物療
法に関する Rapid/Living recommendations【第 4.3 版】2022.3.29.
・Bernal AJ，et al. Molnupiravir for oral treatment of Covid-19 in nonhospitalized patients. N Engl J Med 2021.
・Burwick RM，et al. Compassionate use of remdesivir in pregnant women with severe coronavirus disease 2019.
Clin Infect Dis 2021.
・Chen P，et al. SARS-CoV-2 neutralizing antibody LY-CoV555 in outpatients with Covid-19. N Engl J Med 2020.
・Davis MR，et al. Remdesivir and GS-441524 plasma concentrations in patients with end-stage renal disease on
haemodialysis. J Antimicrob Chemother 2021.
・Diaz GA，et al. Remdesivir and mortality in patients with COVID-19. Clin Infect Dis 2021.
・FDA. Frequently Asked Questions on the Emergency Use Authorization for Actemra (Tocilizumab) for Treatment
of COVID-19. 24 June 2021.
・FDA. Frequently Asked Questions on the Emergency Use Authorization of Baricitinib for Treatment of COVID-19.
28 Jul 2021.
・Goldman JD，et al. Remdesivir for 5 or 10 days in patients with severe Covid-19. N Engl J Med 2020.
・Gottleib RL，et al. Early remdesivir to prevent progression to severe Covid-19 in outpatients. N Engl J Med 2021.
・Gupta A，et al. Early treatment for Covid-19 with SARS-CoV-2 neutralizing antibody sotrovimab. N Engl J Med 2021.
・Hammond J，et al. Oral nirmatrelvir for high-risk，nonhospitalized adults with Covid-19. N Engl J Med 2022.
・Horby PW，et al. Dexamethasone in hospitalized patients with Covid-19 - preliminary report. N Engl J Med 2020.
・Horby PW，et al. Tocilizumab in patients admitted to hospital with COVID-19（RECOVERY）: preliminary results
of
a randomised，controlled，open-label，platform trial. Lancet 2021.
・Kalil AC，et al. Baricitinib plus remdesivir for hospitalized adults with Covid-19. N Engl J Med 2020.
・Kikuchi K，et al. Survival and predictive factors in dialysis patients with COVID-19 in Japan: a nationwide cohort
study. Ren Replace Ther 2021.
・Marconi VC，et al. EEfficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19
(COV-BARRIER): a randomised，double-blind，parallel-group，placebo-controlled phase 3 trial. Lancet Respir Med
2021.
・Mozaffari E，et al. Remdesivir treatment in hospitalized patients with COVID-19: a comparative analysis of inhospital all-cause mortality in a large multi-center observational cohort. Clin Infect Dis 2021.
・NIH. Coronavirus diseases 2019（COVID-19）treatment guidelines. 31 May 2022.
・Nithya G，et al. A clinical study on the changing dynamics of disease severity，management strategies and
outcomes of COVID-19 in patients requiring haemodialysis. J Nephrol 2021.
・Pan H，et al. Repurposed antiviral drugs for Covid-19 - Interim WHO solidarity trial results. N Engl J Med 2020.
・Salama C，et al. Tocilizumab in patients hospitalized with Covid-19 pneumonia. N Engl J Med 2020.
・Salvarani C，et al. Effect of tocilizumab vs standard care on clinical worsening in patients hospitalized with
COVID-19 pneumonia : a randomized clinical trial. JAMA Intern Med 2020.
・ Shankar-Hari M，et al. Association between administration of IL-6 antagonists and mortality among patients
hospitalized or COVID-19: A meta-analysis. JAMA 2021.
・Siemieniul RA，et al. Antibody and cellular therapies for treatment of covid-19: a living systematic review and
network meta-analysis. BMJ 2021.
・Somers EC，et al. Tocilizumab for treatment of mechanically ventilated patients with COVID-19. Clin Infect Dis
2020.
・Stone JH，et al. Efficacy of tocilizumab in patients hospitalized with Covid-19. N Engl J Med 2020.
・Takashita E，et al. Efficacy of antibodies and antiviral drugs against Covid-19 omicron variant. N Engl J Med
2022.
・Takashita，et al. Efficacy of antiviral agents against the SARS-CoV-2 omicron subvariant BA.2. N Engl J Med
2022.
・Takashita，et al. Efficacy of antibodies and antiviral drugs against omicron BA.2.12.1，BA.4，and BA.5
subvariants.
N Engl J Med 2022.
・Weinreich DM，et al. REGN-COV2，a neutralizing antibody cocktail，in outpatients with Covid-19. N Engl J Med
2021.
・Weinreich DM，et al. REGEN-COV antibody combination and outcomes in outpatients with Covid-19. N Engl J
Med
2021.
・WHO. Therapeutics and COVID-19：living guidance. 22 Apr 2022.
◀︎ CONTENTS
62
◆引用・参考文献◆
・日本感染症学会．COVID-19 に対する薬物治療の考え方（第 14.2 版）
．2022.9.30.
・日本救急医学会・日本集中治療医学会．日本版敗血症診療ガイドライン 2020（J-SSCG2020）特別編，COVID-19 薬物療
法に関する Rapid/Living recommendations【第 4.3 版】2022.3.29.
・Bernal AJ，et al. Molnupiravir for oral treatment of Covid-19 in nonhospitalized patients. N Engl J Med 2021.
・Burwick RM，et al. Compassionate use of remdesivir in pregnant women with severe coronavirus disease 2019.
Clin Infect Dis 2021.
・Chen P，et al. SARS-CoV-2 neutralizing antibody LY-CoV555 in outpatients with Covid-19. N Engl J Med 2020.
・Davis MR，et al. Remdesivir and GS-441524 plasma concentrations in patients with end-stage renal disease on
haemodialysis. J Antimicrob Chemother 2021.
・Diaz GA，et al. Remdesivir and mortality in patients with COVID-19. Clin Infect Dis 2021.
・FDA. Frequently Asked Questions on the Emergency Use Authorization for Actemra (Tocilizumab) for Treatment
of COVID-19. 24 June 2021.
・FDA. Frequently Asked Questions on the Emergency Use Authorization of Baricitinib for Treatment of COVID-19.
28 Jul 2021.
・Goldman JD，et al. Remdesivir for 5 or 10 days in patients with severe Covid-19. N Engl J Med 2020.
・Gottleib RL，et al. Early remdesivir to prevent progression to severe Covid-19 in outpatients. N Engl J Med 2021.
・Gupta A，et al. Early treatment for Covid-19 with SARS-CoV-2 neutralizing antibody sotrovimab. N Engl J Med 2021.
・Hammond J，et al. Oral nirmatrelvir for high-risk，nonhospitalized adults with Covid-19. N Engl J Med 2022.
・Horby PW，et al. Dexamethasone in hospitalized patients with Covid-19 - preliminary report. N Engl J Med 2020.
・Horby PW，et al. Tocilizumab in patients admitted to hospital with COVID-19（RECOVERY）: preliminary results
of
a randomised，controlled，open-label，platform trial. Lancet 2021.
・Kalil AC，et al. Baricitinib plus remdesivir for hospitalized adults with Covid-19. N Engl J Med 2020.
・Kikuchi K，et al. Survival and predictive factors in dialysis patients with COVID-19 in Japan: a nationwide cohort
study. Ren Replace Ther 2021.
・Marconi VC，et al. EEfficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19
(COV-BARRIER): a randomised，double-blind，parallel-group，placebo-controlled phase 3 trial. Lancet Respir Med
2021.
・Mozaffari E，et al. Remdesivir treatment in hospitalized patients with COVID-19: a comparative analysis of inhospital all-cause mortality in a large multi-center observational cohort. Clin Infect Dis 2021.
・NIH. Coronavirus diseases 2019（COVID-19）treatment guidelines. 31 May 2022.
・Nithya G，et al. A clinical study on the changing dynamics of disease severity，management strategies and
outcomes of COVID-19 in patients requiring haemodialysis. J Nephrol 2021.
・Pan H，et al. Repurposed antiviral drugs for Covid-19 - Interim WHO solidarity trial results. N Engl J Med 2020.
・Salama C，et al. Tocilizumab in patients hospitalized with Covid-19 pneumonia. N Engl J Med 2020.
・Salvarani C，et al. Effect of tocilizumab vs standard care on clinical worsening in patients hospitalized with
COVID-19 pneumonia : a randomized clinical trial. JAMA Intern Med 2020.
・ Shankar-Hari M，et al. Association between administration of IL-6 antagonists and mortality among patients
hospitalized or COVID-19: A meta-analysis. JAMA 2021.
・Siemieniul RA，et al. Antibody and cellular therapies for treatment of covid-19: a living systematic review and
network meta-analysis. BMJ 2021.
・Somers EC，et al. Tocilizumab for treatment of mechanically ventilated patients with COVID-19. Clin Infect Dis
2020.
・Stone JH，et al. Efficacy of tocilizumab in patients hospitalized with Covid-19. N Engl J Med 2020.
・Takashita E，et al. Efficacy of antibodies and antiviral drugs against Covid-19 omicron variant. N Engl J Med
2022.
・Takashita，et al. Efficacy of antiviral agents against the SARS-CoV-2 omicron subvariant BA.2. N Engl J Med
2022.
・Takashita，et al. Efficacy of antibodies and antiviral drugs against omicron BA.2.12.1，BA.4，and BA.5
subvariants.
N Engl J Med 2022.
・Weinreich DM，et al. REGN-COV2，a neutralizing antibody cocktail，in outpatients with Covid-19. N Engl J Med
2021.
・Weinreich DM，et al. REGEN-COV antibody combination and outcomes in outpatients with Covid-19. N Engl J
Med
2021.
・WHO. Therapeutics and COVID-19：living guidance. 22 Apr 2022.
◀︎ CONTENTS
62