表 1．患者背景（続き）
バンデタニブ
患者数（人）
年齢
0-9 歳
10-19 歳
20-29 歳
30-39 歳
40-49 歳
50-59 歳
60-69 歳
70-79 歳
80-89 歳
90 歳以上
性別
女性
男性
既往歴
動脈解離
心血管系イベント
高血圧症
糖尿病
脂質異常症
適応症
不明
肺癌
胃癌
乳癌
大腸・結腸癌
腎細胞癌
肝細胞癌
膵腫瘍
子宮頸癌
卵巣癌
甲状腺癌
消化管間質腫瘍
軟部腫瘍
神経膠腫
間質性肺疾患

102

ベバシズマブ
（遺伝子組換え）
278,722

ラムシルマブ
（遺伝子組換え）
73,593

レゴラフェニブ水和物
25,691

レンバチニブ
メシル酸塩
20,359

カボザンチニブ
リンゴ酸塩
0

0
<10
<10
<10
13
17
34
22
<10
<10

0%
<9.80%
<9.80%
<9.80%
12.75%
16.67%
33.33%
21.57%
<9.80%
<9.80%

347
386
1,150
6,579
23,140
46,357
95,495
85,335
19,558
375

0.12%
0.14%
0.41%
2.36%
8.30%
16.63%
34.26%
30.62%
7.02%
0.13%

<10
<10
139
986
3732
8861
25848
28271
5661
86

<0.01%
<0.01%
0.19%
1.34%
5.07%
12.04%
35.12%
38.42%
7.69%
0.12%

0
15
51
360
1456
3771
9104
8869
2033
32

0%
0.06%
0.20%
1.40%
5.67%
14.68%
35.44%
34.52%
7.91%
0.12%

0
<10
<30
82
441
1400
4937
8658
4606
204

0%
<0.05%
<0.15%
0.40%
2.17%
6.88%
24.25%
42.53%
22.62%
1.00%

0
0
0
0
0
0
0
0
0
0

0%
0%
0%
0%
0%
0%
0%
0%
0%
0%

39
63

38.24%
61.76%

143,338
135,384

51.43%
48.57%

22818
50775

31.01%
68.99%

9455
16236

36.80%
63.20%

5805
14554

28.51%
71.49%

0
0

0%
0%

0
<10
37
18
16

0%
<9.80%
36.27%
17.65%
15.69%

215
2,064
81,269
33,487
54,662

0.08%
0.74%
29.16%
12.01%
19.61%

100
1131
28622
11902
17390

0.14%
1.54%
38.89%
16.17%
23.63%

55
301
12699
4814
5683

0.21%
1.17%
49.43%
18.74%
22.12%

40
518
12094
6580
5159

0.20%
2.54%
59.40%
32.32%
25.34%

0
0
0
0
0

0%
0%
0%
0%
0%

<10
0
0
0
0
0
0
0
0
0
<102
0
0
0
0

<9.80%
0%
0%
0%
0%
0%
0%
0%
0%
0%
<100%
0%
0%
0%
0%

11,020
47,114
0
32,932
158,149
0
1,158
0
5,283
17,706
0
0
0
12,664
0

3.95%
16.9%
0%
11.82%
56.74%
0%
0.42%
0%
1.90%
6.35%
0%
0%
0%
4.54%
0%

3,613
13,695
41,802
0
15,954
0
1,215
0
0
0
0
0
0
0
0

4.91%
18.61%
56.80%
0%
21.68%
0%
1.65%
0%
0%
0%
0%
0%
0%
0%
0%

542
0
0
0
21,426
0
3,052
0
0
0
0
1,089
0
0
0

2.11%
0%
0%
0%
83%
0%
11.88%
0%
0%
0%
0%
4.24%
0%
0%
0%

151
0
0
0
0
0
15,934
0
0
0
4,481
0
0
0
0

0.74%
0%
0%
0%
0%
0%
78.27%
0%
0%
0%
22.01%
0%
0%
0%
0%

0
0
0
0
0
0
0
0
0
0
0
0
0
0
0

0%
0%
0%
0%
0%
0%
0%
0%
0%
0%
0%
0%
0%
0%
0%

2

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