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資 料４－２－➁ 令和４年度第２回安全技術調査会の審議結果について➁ (198 ページ)
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Joint UKBTS Professional Advisory Committee (')
Summary Sheet
| PA Joint United Kingdom (UK) Blood Transfusion and Tissue
Transplantation Services Professional Advisory Committee Position Statement
Monkeypox virus (MPXV)
May 2022
Approved py: Sandjng Advsory Comm誠ee o7 77anS娘SOn 77g7nS77/ffed /779c0o7S
May 2022- 7カe confenfSs oげの/S ocurmenf are be/jeved fo De Current P/ease conがnue
fo re7er fo 妨e weps/fe fo 旋-びafe verS7OnS-.
Infection and viraemia
Unlike respiratory viruses (e.d. SARS-CoV-2), MPXV does not spread easily between individualSs.
Human-to-human transmission occurs through close contact with infectious material from skin
lesions of an infected person, through respiratory droplets in prolonged face-to-face contact, and
through virus-contaminated fomites such as bedding or clothing9. A secondary attack rate of
approximately 8% (range 0-11%) for unvaccinated household contacts has been estimated!. In this
current multi-country outbreak, the presentation of the lesions in certain cases indicate that
transmiSsion IS Occurring during Sexual contact.
In infected individuals MPXV DNA has been detected in blood. A retrospective review of MPX
symptomatic cases treated in UK between August 2018 and September 2021 demonstrated MPXV
DNA in the bloodstream in 6 of 7 individuals, with viraemia fluctuating for 27-29 days in 2 of the
caseSs. Furthermore, virus was detected in blood after the clearance of rash in 2 cases'. MPXV DNA
was detected in upper respiratory tract swabs in all 7 cases and for at least 3 weeks in 3 patients.
In a MPX outbreak in the US, 14 blood samples collected 21 days after the appearance of rash were
negative for MPXV DNA. There are no good data on viraemia in asymptomatic (most, if not all, cases
are thought to develop symptoms) or pre-symptomatic individuals. However, virus can be detected
in the blood, tissues and organs of MPXV-infected animalSs.
41(
Summary Sheet
| PA Joint United Kingdom (UK) Blood Transfusion and Tissue
Transplantation Services Professional Advisory Committee Position Statement
Monkeypox virus (MPXV)
May 2022
Approved py: Sandjng Advsory Comm誠ee o7 77anS娘SOn 77g7nS77/ffed /779c0o7S
May 2022- 7カe confenfSs oげの/S ocurmenf are be/jeved fo De Current P/ease conがnue
fo re7er fo 妨e weps/fe fo 旋-びafe verS7OnS-.
Infection and viraemia
Unlike respiratory viruses (e.d. SARS-CoV-2), MPXV does not spread easily between individualSs.
Human-to-human transmission occurs through close contact with infectious material from skin
lesions of an infected person, through respiratory droplets in prolonged face-to-face contact, and
through virus-contaminated fomites such as bedding or clothing9. A secondary attack rate of
approximately 8% (range 0-11%) for unvaccinated household contacts has been estimated!. In this
current multi-country outbreak, the presentation of the lesions in certain cases indicate that
transmiSsion IS Occurring during Sexual contact.
In infected individuals MPXV DNA has been detected in blood. A retrospective review of MPX
symptomatic cases treated in UK between August 2018 and September 2021 demonstrated MPXV
DNA in the bloodstream in 6 of 7 individuals, with viraemia fluctuating for 27-29 days in 2 of the
caseSs. Furthermore, virus was detected in blood after the clearance of rash in 2 cases'. MPXV DNA
was detected in upper respiratory tract swabs in all 7 cases and for at least 3 weeks in 3 patients.
In a MPX outbreak in the US, 14 blood samples collected 21 days after the appearance of rash were
negative for MPXV DNA. There are no good data on viraemia in asymptomatic (most, if not all, cases
are thought to develop symptoms) or pre-symptomatic individuals. However, virus can be detected
in the blood, tissues and organs of MPXV-infected animalSs.
41(