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【別添】新型コロナウイルス感染症（COVID-19）診療の手引き別冊罹患後症状のマネジメント（第３.０版） (62 ページ)
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●新型コロナウイルス感染症（COVID-19） 診療の手引き
別冊
罹患後症状のマネジメント・第 3.0 版 ● 10 小児へのアプローチ
◆引用・参考文献◆
・国立成育医療研究センター コロナこども本部．コロナ禍における思春期のこどもとその保護者のこころの実態報告書．2022
年 3 月 23 日（修正 2022 年 6 月 15 日）. https://www.ncchd.go.jp/center/activity/covid19_kodomo/report/CxCN_
repo.pdf
・診療の手引き検討委員会 . 新型コロナウイルス感染症 COVID-19 診療の手引き . 第 10.0 版 . https://www.mhlw.go.jp/
content/001136720.pdf
・田中英高 . 起立性調節障害 (OD). https://www.jisinsin.jp/general/detail/detail_01/（2022 年 3 月 28 日アクセス）
・Adler L, et al. Long COVID symptoms in Israeli children with and without a history of SARS-CoV-2 infection: crosssectional study. BMJ Open. 13: e064155, 2023.
・Blankenburg J, et al. Comparison of mental health outcomes in seropositive and seronegative adolescents during
the COVID19 pandemic. Sci Rep.12: 2246, 2022.
・Borch L, et al. Long COVID symptoms and duration in SARS-CoV-2 positive children – a nationwide cohort study.
Eur J Pediatr. 181: 1597-607, 2022.
・Buonsenso D, et al. Risk of long Covid in children infected with Omicron or pre-Omicron SARS-CoV-2 variants.
Acta Paediatr 112: 1284-6, 2023.
・Erol N, et al. Intriguing new faces of Covid-19: persisting clinical symptoms and cardiac effects in children. Cardiol
Young. 32: 1085-91, 2022..
・Fink TT, et al. Persistent symptoms and decreased health-related quality of life after symptomatic pediatric
COVID-19: a prospective study in a Latin American tertiary hospital. Clinic.76: e3511, 2021.
・Funk AL, et al. Post-COVID-19 conditions among children 90 days after SARS-CoV-2 infection. JAMA Network
Open. 5(7): e2223253, 2022.
・Heiss R, et al. Pulmonary dysfunction after pediatric COVID-19. Radiology. Sep 20, 2022.
・Kikkenborg-Berg S, et al. Long COVID symptoms in SARS-CoV-2-positive children aged 0-14 years and matched
controls in Denmark (LongCOVIDKidsDK): A national, cross-sectional study. Lancet Child Adolesc Health. 6:
614-23, 2022.
・Kompaniyets L, et al. Post-COVID-19 symptoms and conditions among children and adolescents – United States,
March 1, 2020 – January 21. MMWR. 71: 993-9, 2022.
・Molteni E, et al. Illness duration and symptom profile in symptomatic UK school-aged children tested for SARSCoV-2. Lancet Child Adolesc Health. 5: 708-18, 2021.
・Radtke T, et al. Long-term symptoms after SARS-CoV-2 infection in children and adolescents. JAMA. 326:
869-71, 2021.
・Rao S, Lee GM, et al. Clinical features and burden of postacute sequelae of SARS-CoV-2 infection in children and
adolescents. JAMA Pediatr. 176: 1000-9, 2022.
・Roessler M, et al. Post COVID-19-associated morbidity in children, adolescents, and adults: a matched cohort
including more than 157,000 individuals with COVID-19 in Germany. PLoS Med. 19: e1004122, 2022.
・Roge I, et al. Comparison of persistent symptoms after COVID-19 and other non-SARS-CoV-2 infections in
children. Front Pediatr. 9: 752385, 2021.
・Selvakumar J, et al. Prevalence and characteristics associated with post-COVID-19 condition among
nonhospitalized adolescents and young adults. JAMA Network Open. 6: e235763, 2023.
・Serry V, et al. Persistent symptoms after COVID-19 in children and adolescents from Argentina. Int J Infect Dis.
129: 49-56, 2023.
・Son MBF, et al. COVID-19: Multisystem inflammatory syndrome in children (MIS-C) management and outcome.
UpToDate. https://www.uptodate.com/contents/covid-19-multisystem-inflammatory-syndrome-in-children-mis-cmanagement-and-outcome（2023 年 9 月 5 日アクセス）
・Sorg A-L, et al. Association of SARS-CoV-2 seropositivity with myalgic encephalomyelitis and/or chronic fatigue
syndrome among children and adolescents in Germany. JAMA Network Open 5: e2233454, 2022.
・Stephenson T, et al. Long COVID – the physical and mental health of children and non-hospitalised young people 3
months after SARS-CoV-2 infection; a national matched cohort study (The CLoCk) study．Lancet Child Adoles
Health. 6: 230-9, 2022.
・WHO. A clinical case definition for post COVID-19 condition in children and adolescents by expert consensus, 16
February 2023.
・WHO/2019-nCoV/Post_COVID-19_condition/CA/Clinical_case_definition/2023.1
https://iris.who.int/bitstream/handle/10665/366126/WHO-2019-nCoV-Post-COVID-19-condition-CA-Clinicalcase-definition-2023.1-eng.pdf?sequence=1
・Zavala M, et al. Acute and persistent symptoms in children with polymerase chain reaction (PCR)-confirmed severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection compared with test-negative children in
England: acute, prospective, national surveillance. Clin Infect Dis.75: e191-200, 2022.
◀︎目次
61
別冊
罹患後症状のマネジメント・第 3.0 版 ● 10 小児へのアプローチ
◆引用・参考文献◆
・国立成育医療研究センター コロナこども本部．コロナ禍における思春期のこどもとその保護者のこころの実態報告書．2022
年 3 月 23 日（修正 2022 年 6 月 15 日）. https://www.ncchd.go.jp/center/activity/covid19_kodomo/report/CxCN_
repo.pdf
・診療の手引き検討委員会 . 新型コロナウイルス感染症 COVID-19 診療の手引き . 第 10.0 版 . https://www.mhlw.go.jp/
content/001136720.pdf
・田中英高 . 起立性調節障害 (OD). https://www.jisinsin.jp/general/detail/detail_01/（2022 年 3 月 28 日アクセス）
・Adler L, et al. Long COVID symptoms in Israeli children with and without a history of SARS-CoV-2 infection: crosssectional study. BMJ Open. 13: e064155, 2023.
・Blankenburg J, et al. Comparison of mental health outcomes in seropositive and seronegative adolescents during
the COVID19 pandemic. Sci Rep.12: 2246, 2022.
・Borch L, et al. Long COVID symptoms and duration in SARS-CoV-2 positive children – a nationwide cohort study.
Eur J Pediatr. 181: 1597-607, 2022.
・Buonsenso D, et al. Risk of long Covid in children infected with Omicron or pre-Omicron SARS-CoV-2 variants.
Acta Paediatr 112: 1284-6, 2023.
・Erol N, et al. Intriguing new faces of Covid-19: persisting clinical symptoms and cardiac effects in children. Cardiol
Young. 32: 1085-91, 2022..
・Fink TT, et al. Persistent symptoms and decreased health-related quality of life after symptomatic pediatric
COVID-19: a prospective study in a Latin American tertiary hospital. Clinic.76: e3511, 2021.
・Funk AL, et al. Post-COVID-19 conditions among children 90 days after SARS-CoV-2 infection. JAMA Network
Open. 5(7): e2223253, 2022.
・Heiss R, et al. Pulmonary dysfunction after pediatric COVID-19. Radiology. Sep 20, 2022.
・Kikkenborg-Berg S, et al. Long COVID symptoms in SARS-CoV-2-positive children aged 0-14 years and matched
controls in Denmark (LongCOVIDKidsDK): A national, cross-sectional study. Lancet Child Adolesc Health. 6:
614-23, 2022.
・Kompaniyets L, et al. Post-COVID-19 symptoms and conditions among children and adolescents – United States,
March 1, 2020 – January 21. MMWR. 71: 993-9, 2022.
・Molteni E, et al. Illness duration and symptom profile in symptomatic UK school-aged children tested for SARSCoV-2. Lancet Child Adolesc Health. 5: 708-18, 2021.
・Radtke T, et al. Long-term symptoms after SARS-CoV-2 infection in children and adolescents. JAMA. 326:
869-71, 2021.
・Rao S, Lee GM, et al. Clinical features and burden of postacute sequelae of SARS-CoV-2 infection in children and
adolescents. JAMA Pediatr. 176: 1000-9, 2022.
・Roessler M, et al. Post COVID-19-associated morbidity in children, adolescents, and adults: a matched cohort
including more than 157,000 individuals with COVID-19 in Germany. PLoS Med. 19: e1004122, 2022.
・Roge I, et al. Comparison of persistent symptoms after COVID-19 and other non-SARS-CoV-2 infections in
children. Front Pediatr. 9: 752385, 2021.
・Selvakumar J, et al. Prevalence and characteristics associated with post-COVID-19 condition among
nonhospitalized adolescents and young adults. JAMA Network Open. 6: e235763, 2023.
・Serry V, et al. Persistent symptoms after COVID-19 in children and adolescents from Argentina. Int J Infect Dis.
129: 49-56, 2023.
・Son MBF, et al. COVID-19: Multisystem inflammatory syndrome in children (MIS-C) management and outcome.
UpToDate. https://www.uptodate.com/contents/covid-19-multisystem-inflammatory-syndrome-in-children-mis-cmanagement-and-outcome（2023 年 9 月 5 日アクセス）
・Sorg A-L, et al. Association of SARS-CoV-2 seropositivity with myalgic encephalomyelitis and/or chronic fatigue
syndrome among children and adolescents in Germany. JAMA Network Open 5: e2233454, 2022.
・Stephenson T, et al. Long COVID – the physical and mental health of children and non-hospitalised young people 3
months after SARS-CoV-2 infection; a national matched cohort study (The CLoCk) study．Lancet Child Adoles
Health. 6: 230-9, 2022.
・WHO. A clinical case definition for post COVID-19 condition in children and adolescents by expert consensus, 16
February 2023.
・WHO/2019-nCoV/Post_COVID-19_condition/CA/Clinical_case_definition/2023.1
https://iris.who.int/bitstream/handle/10665/366126/WHO-2019-nCoV-Post-COVID-19-condition-CA-Clinicalcase-definition-2023.1-eng.pdf?sequence=1
・Zavala M, et al. Acute and persistent symptoms in children with polymerase chain reaction (PCR)-confirmed severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection compared with test-negative children in
England: acute, prospective, national surveillance. Clin Infect Dis.75: e191-200, 2022.
◀︎目次
61