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【参考資料4】抗微生物薬適正使用の手引き 第三版 本編 (128 ページ)
出典
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| 出典情報 | 厚生科学審議会 感染症部会 薬剤耐性（AMR）に関する小委員会 抗微生物薬適正使用（AMS）等に関する作業部会（第6回 11／19）《厚生労働省》 |
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抗微生物薬適正使用の手引き
第三版
18. Vincent JL, et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure
in intensive care units: results of a multicenter, prospective study. Working group on "sepsisrelated problems" of the European Society of Intensive Care Medicine. Crit Care Med.
1998;26(11):1793-1800.
19. Spellberg B, Srinivasan A, Chambers HF. New Societal Approaches to Empowering Antibiotic
Stewardship. JAMA. 2016;315(12):1229-1230.
20. Willems RPJ, van Dijk K, Vehreschild MJGT, et al. Incidence of infection with multidrugresistant Gram-negative bacteria and vancomycin-resistant enterococci in carriers: a
systematic review and meta-regression analysis. The Lancet Infectious Diseases. 2023.
21. 抗菌薬適正使用支援プログラム実践のためのガイダンス 8 学会合同抗微生物薬適正使用推進
検討委員会 感染症学雑誌, 第 91 巻, 第 5 号
https://www.kansensho.or.jp/uploads/files/guidelines/1708_ASP_guidance.pdf
22. Dryden M, et al. Using antibiotics responsibly: right drug, right time, right dose, right duration.
J Antimicrob Chemother. 2011;66(11):2441-2443.
23. Schuler F, Froböse N, Schaumburg F. Prevalence and risk factors for bacteremia in patients
with Staphylococcus aureus bacteriuria: A retrospective cohort study. Int J Infect Dis.
2020;98:467-469.
24. Weinstein MP, et al. The clinical significance of positive blood cultures in the 1990s: a
prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of
bacteremia and fungemia in adults. Clin Infect Dis. 1997;24(4):584-602.
25. Pien BC, et al. The clinical and prognostic importance of positive blood cultures in adults. Am
J Med 2010; 123(9): 819-828
26. Hodnett ED, et al. Re-conceptualizing the hospital labor room: the PLACE (pregnant and
laboring in an ambient clinical environment) pilot trial. Birth, 2009;36(2):159-166.
27. Torres A, et al. International ERS/ESICM/ESCMID/ALAT guidelines for the management of
hospital-acquired pneumonia and ventilator-associated pneumonia: Guidelines for the
management of hospital-acquired pneumonia (HAP)/ventilator-associated pneumonia (VAP)
of the European Respiratory Society (ERS), European Society of Intensive Care Medicine
(ESICM), European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and
Asociación Latinoamericana del Tórax (ALAT). Eur Respir J. 2017;50(3):1700582.
28. Janmaimool P, Watanabe T. Evaluating determinants of environmental risk perception for risk
management in contaminated sites. Int J Environ Res Public Health. 2014;11(6):6291-6313.
29. Gupta K, Hooton TM, Naber KG, et al. International clinical practice guidelines for the
treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the
Infectious Diseases Society of America and the European Society for Microbiology and
Infectious Diseases. Clin Infect Dis. Mar 1 2011;52(5):e103-120.
30. Pardo J, Klinker KP, Borgert SJ, Trikha G, Rand KH, Ramphal R. Time to positivity of blood
cultures supports antibiotic de-escalation at 48 hours. The Annals of pharmacotherapy.
2014;48(1):33-40.
31. Puerta-Alcalde P, Cardozo C, Suarez-Lledo M, et al. Current time-to-positivity of blood
cultures in febrile neutropenia: a tool to be used in stewardship de-escalation strategies. Clin
Microbiol Infect. Apr 2019;25(4):447-453.
128
第三版
18. Vincent JL, et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure
in intensive care units: results of a multicenter, prospective study. Working group on "sepsisrelated problems" of the European Society of Intensive Care Medicine. Crit Care Med.
1998;26(11):1793-1800.
19. Spellberg B, Srinivasan A, Chambers HF. New Societal Approaches to Empowering Antibiotic
Stewardship. JAMA. 2016;315(12):1229-1230.
20. Willems RPJ, van Dijk K, Vehreschild MJGT, et al. Incidence of infection with multidrugresistant Gram-negative bacteria and vancomycin-resistant enterococci in carriers: a
systematic review and meta-regression analysis. The Lancet Infectious Diseases. 2023.
21. 抗菌薬適正使用支援プログラム実践のためのガイダンス 8 学会合同抗微生物薬適正使用推進
検討委員会 感染症学雑誌, 第 91 巻, 第 5 号
https://www.kansensho.or.jp/uploads/files/guidelines/1708_ASP_guidance.pdf
22. Dryden M, et al. Using antibiotics responsibly: right drug, right time, right dose, right duration.
J Antimicrob Chemother. 2011;66(11):2441-2443.
23. Schuler F, Froböse N, Schaumburg F. Prevalence and risk factors for bacteremia in patients
with Staphylococcus aureus bacteriuria: A retrospective cohort study. Int J Infect Dis.
2020;98:467-469.
24. Weinstein MP, et al. The clinical significance of positive blood cultures in the 1990s: a
prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of
bacteremia and fungemia in adults. Clin Infect Dis. 1997;24(4):584-602.
25. Pien BC, et al. The clinical and prognostic importance of positive blood cultures in adults. Am
J Med 2010; 123(9): 819-828
26. Hodnett ED, et al. Re-conceptualizing the hospital labor room: the PLACE (pregnant and
laboring in an ambient clinical environment) pilot trial. Birth, 2009;36(2):159-166.
27. Torres A, et al. International ERS/ESICM/ESCMID/ALAT guidelines for the management of
hospital-acquired pneumonia and ventilator-associated pneumonia: Guidelines for the
management of hospital-acquired pneumonia (HAP)/ventilator-associated pneumonia (VAP)
of the European Respiratory Society (ERS), European Society of Intensive Care Medicine
(ESICM), European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and
Asociación Latinoamericana del Tórax (ALAT). Eur Respir J. 2017;50(3):1700582.
28. Janmaimool P, Watanabe T. Evaluating determinants of environmental risk perception for risk
management in contaminated sites. Int J Environ Res Public Health. 2014;11(6):6291-6313.
29. Gupta K, Hooton TM, Naber KG, et al. International clinical practice guidelines for the
treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the
Infectious Diseases Society of America and the European Society for Microbiology and
Infectious Diseases. Clin Infect Dis. Mar 1 2011;52(5):e103-120.
30. Pardo J, Klinker KP, Borgert SJ, Trikha G, Rand KH, Ramphal R. Time to positivity of blood
cultures supports antibiotic de-escalation at 48 hours. The Annals of pharmacotherapy.
2014;48(1):33-40.
31. Puerta-Alcalde P, Cardozo C, Suarez-Lledo M, et al. Current time-to-positivity of blood
cultures in febrile neutropenia: a tool to be used in stewardship de-escalation strategies. Clin
Microbiol Infect. Apr 2019;25(4):447-453.
128