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「日本人の食事摂取基準（2025年版）」策定検討会報告書 (189 ページ)
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risk of total cardiovascular mortality: a systematic review and dose-response meta-analysis of prospective
observational studies. Public Health Nutr. 2019;22(10):1872-1887.
114) Cheng P, Wang L, Ning S, et al. Vitamin E intake and risk of stroke: a meta-analysis. Br J
Nutr. 2018;120(10):1181-1188.
115) Michaëlsson K, Wolk A, Byberg L, et al. Intake and serum concentrations of α-tocopherol in relation to
fractures in elderly women and men: 2 cohort studies. Am J Clin Nutr. 2014;99(1):107-114.
116) Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta
carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J
Med. 1994;330(15):1029-1035.
117) Klein EA, Thompson IM Jr, Tangen CM, et al. Vitamin E and the risk of prostate cancer: the Selenium and
Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2011;306(14):1549-1556.
118) Shearer MJ, Bach A, Kohlmeier M. Chemistry, nutritional sources, tissue distribution and metabolism of
vitamin K with special reference to bone health. J Nutr. 1996;126(4 Suppl):1181S-6S.
119) Schurgers LJ, Vermeer C. Differential lipoprotein transport pathways of K-vitamins in healthy subjects.
Biochim Biophys Acta. 2002;1570(1):27-32.
120) Schurgers LJ, Teunissen KJF, Hamulyák K, et al. Vitamin K-containing dietary supplements: comparison
of synthetic vitamin K1 and natto-derived menaquinone-7. Blood. 2007;109(8):3279-3283.
121) Shea MK, Booth SL. Concepts and controversies in evaluating vitamin K status in population-based studies.
Nutrients. 2016;8(1):8.
122) Shearer MJ. Vitamin K. Lancet. 1995;345(8944):229-234.
123) Nakagawa K, Hirota Y, Sawada N, et al. Identification of UBIAD1 as a novel human menaquinone-4
biosynthetic enzyme. Nature. 2010;468(7320):117-121.
124) Binkley NC, Krueger DC, Kawahara TN, et al. A high phylloquinone intake is required to achieve maximal
osteocalcin gamma-carboxylation. Am J Clin Nutr. 2002;76(5):1055-1060.
125) Shea MK, O’Donnell CJ, Vermeer C, et al. Circulating uncarboxylated matrix gla protein is associated with
vitamin K nutritional status, but not coronary artery calcium, in older adults. J Nutr. 2011;141(8):1529-1534.
126) Tsugawa N, Shiraki M, Suhara Y, et al. Vitamin K status of healthy Japanese women: age-related vitamin
K requirement for gamma-carboxylation of osteocalcin. Am J Clin Nutr. 2006;83(2):380-386.
127) Kamao M, Suhara Y, Tsugawa N, et al. Vitamin K content of foods and dietary vitamin K intake in Japanese
young women. J Nutr Sci Vitaminol (Tokyo). 2007;53(6):464-470.
128) Booth SL. Vitamin K status in the elderly. Curr Opin Clin Nutr Metab Care. 2007;10(1):20-23.
129) Theuwissen E, Magdeleyns EJ, Braam LAJLM, et al. Vitamin K status in healthy volunteers. Food
Funct. 2014;5(2):229-234.
130) Kojima T, Asoh M, Yamawaki N, et al. Vitamin K concentrations in the maternal milk of Japanese women.
Acta Paediatr. 2004;93(4):457-463.
131) 白幡聡, 伊藤進, 高橋幸博, 他. 日本小児科学会新生児委員会 新生児・乳児ビタミン K 欠乏性出
血症に対するビタミン K 製剤投与の改訂ガイドライン（修正版）. 日本小児科学会雑
誌. 2011;115(3):705-712.
132) Institute of Medicine. Vitamin K. In: Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron,
Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. National
179
observational studies. Public Health Nutr. 2019;22(10):1872-1887.
114) Cheng P, Wang L, Ning S, et al. Vitamin E intake and risk of stroke: a meta-analysis. Br J
Nutr. 2018;120(10):1181-1188.
115) Michaëlsson K, Wolk A, Byberg L, et al. Intake and serum concentrations of α-tocopherol in relation to
fractures in elderly women and men: 2 cohort studies. Am J Clin Nutr. 2014;99(1):107-114.
116) Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta
carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J
Med. 1994;330(15):1029-1035.
117) Klein EA, Thompson IM Jr, Tangen CM, et al. Vitamin E and the risk of prostate cancer: the Selenium and
Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2011;306(14):1549-1556.
118) Shearer MJ, Bach A, Kohlmeier M. Chemistry, nutritional sources, tissue distribution and metabolism of
vitamin K with special reference to bone health. J Nutr. 1996;126(4 Suppl):1181S-6S.
119) Schurgers LJ, Vermeer C. Differential lipoprotein transport pathways of K-vitamins in healthy subjects.
Biochim Biophys Acta. 2002;1570(1):27-32.
120) Schurgers LJ, Teunissen KJF, Hamulyák K, et al. Vitamin K-containing dietary supplements: comparison
of synthetic vitamin K1 and natto-derived menaquinone-7. Blood. 2007;109(8):3279-3283.
121) Shea MK, Booth SL. Concepts and controversies in evaluating vitamin K status in population-based studies.
Nutrients. 2016;8(1):8.
122) Shearer MJ. Vitamin K. Lancet. 1995;345(8944):229-234.
123) Nakagawa K, Hirota Y, Sawada N, et al. Identification of UBIAD1 as a novel human menaquinone-4
biosynthetic enzyme. Nature. 2010;468(7320):117-121.
124) Binkley NC, Krueger DC, Kawahara TN, et al. A high phylloquinone intake is required to achieve maximal
osteocalcin gamma-carboxylation. Am J Clin Nutr. 2002;76(5):1055-1060.
125) Shea MK, O’Donnell CJ, Vermeer C, et al. Circulating uncarboxylated matrix gla protein is associated with
vitamin K nutritional status, but not coronary artery calcium, in older adults. J Nutr. 2011;141(8):1529-1534.
126) Tsugawa N, Shiraki M, Suhara Y, et al. Vitamin K status of healthy Japanese women: age-related vitamin
K requirement for gamma-carboxylation of osteocalcin. Am J Clin Nutr. 2006;83(2):380-386.
127) Kamao M, Suhara Y, Tsugawa N, et al. Vitamin K content of foods and dietary vitamin K intake in Japanese
young women. J Nutr Sci Vitaminol (Tokyo). 2007;53(6):464-470.
128) Booth SL. Vitamin K status in the elderly. Curr Opin Clin Nutr Metab Care. 2007;10(1):20-23.
129) Theuwissen E, Magdeleyns EJ, Braam LAJLM, et al. Vitamin K status in healthy volunteers. Food
Funct. 2014;5(2):229-234.
130) Kojima T, Asoh M, Yamawaki N, et al. Vitamin K concentrations in the maternal milk of Japanese women.
Acta Paediatr. 2004;93(4):457-463.
131) 白幡聡, 伊藤進, 高橋幸博, 他. 日本小児科学会新生児委員会 新生児・乳児ビタミン K 欠乏性出
血症に対するビタミン K 製剤投与の改訂ガイドライン（修正版）. 日本小児科学会雑
誌. 2011;115(3):705-712.
132) Institute of Medicine. Vitamin K. In: Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron,
Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. National
179